Prothiaden (Dothiepin) Information

The active ingredient in Prothiaden is **Dothiepin** (also known as **Dosulepin**). Inactive ingredients may include lactose, magnesium stearate, and other excipients.

Common side effects of Prothiaden include:

• Drowsiness
• Dry mouth
• Constipation
• Blurred vision
• Weight gain
• Dizziness

Less common but serious side effects include:

• Severe mood changes (e.g., suicidal thoughts)
• Heart irregularities (e.g., rapid heart rate, fainting)
• Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
• Seizures
• Liver problems (e.g., jaundice)

If you experience any serious side effects, seek medical help immediately.

Prothiaden is usually taken **once or twice daily**, preferably in the evening or at bedtime to reduce daytime drowsiness. It is taken orally, with or without food. The dosage should be adjusted according to the doctor's prescription.

Prothiaden may interact with other medications, including:

• Other antidepressants (e.g., SSRIs, SNRIs): May increase the risk of serotonin syndrome.
• Alcohol: Can enhance sedative effects and impair cognitive function.
• Anticholinergic drugs (e.g., antihistamines): Can increase side effects like dry mouth and constipation.
• Blood pressure medications: Prothiaden can interact with antihypertensive drugs, increasing the risk of low blood pressure.

Always inform your healthcare provider about any other medications you are taking.

It may take **2-4 weeks** for Prothiaden to start showing its full effects in treating depression and anxiety. Continue taking the medication as prescribed even if you don't feel immediate improvement.

If you experience severe side effects, such as suicidal thoughts, heart irregularities, or seizures, stop taking Prothiaden and seek medical attention immediately.